MOTS-c

• AMPK pathway (reported)
• Folate–methionine cycle metabolites (reported)

Reported to influence metabolic regulation via AMPK signalling and the folate cycle. As with other mitochondrial-derived peptides, whether exogenously administered peptide reproduces endogenous signalling is unresolved.

Cell and rodent studies. No completed human efficacy trials known to this entry.

No regulatory authority has assessed this compound as safe or effective for any human indication. The published record is predominantly laboratory and animal work, which does not establish human safety. Supplied and discussed here strictly as a laboratory research material. Not a medicine, not for human or veterinary administration, and nothing on this page should be read as a dosing, treatment or safety recommendation.

Identity by high-resolution mass spectrometry against the expected mass, purity by RP-HPLC with UV detection. For a sequence-defined peptide, enzymatic digestion followed by peptide mapping gives far stronger identity evidence than mass alone, because isomers and closely related sequences can share a mass.

Not an approved medicine.