Triptorelin
Also known as: AY-25650 · D-Trp-6-LHRH
A GnRH agonist carrying a D-tryptophan substitution at position 6, giving greatly increased potency and duration relative to native GnRH. An approved medicine in many jurisdictions.
Development status: Approved as a medicine in one or more jurisdictions
Identifiers and molecular characteristics
- CAS number
- Not verified
- Molecular formula
- Not verified
- Molecular mass
- Not verified
- Amino-acid sequence
- Not verified
- PubChem CID
- Not verified
Identifiers are published only with a source and a check date. Fields marked “not verified” have not yet been confirmed against a primary source — we show the gap rather than an unchecked figure. Always confirm against the certificate of analysis for the specific lot you hold.
Biological targets
- GnRH receptor
Mechanism of action
Substituting a D-amino acid at position 6 resists enzymatic cleavage and raises receptor affinity. As with other long-acting GnRH agonists, sustained stimulation downregulates the receptor and suppresses gonadotropin release after an initial surge.
Research evidence and its limits
Long clinical history with regulatory approval in multiple jurisdictions across oncology, endocrinology and reproductive medicine.
Safety considerations
Where this compound is an approved medicine, the authoritative safety source is the product labelling issued by the relevant regulator — not this page. Research-grade material is not pharmaceutical product and carries none of those assurances. Supplied and discussed here strictly as a laboratory research material. Not a medicine, not for human or veterinary administration, and nothing on this page should be read as a dosing, treatment or safety recommendation.
Analytical identification and quality testing
Identity by high-resolution mass spectrometry against the expected mass, purity by RP-HPLC with UV detection. Tandem MS sequencing or peptide mapping gives stronger identity evidence than mass alone.
Regulatory status
Approved in many jurisdictions. Confirm Indian availability with CDSCO.
Frequently asked questions
Why does a GnRH agonist suppress rather than stimulate the reproductive axis?
Because the axis responds to pulsatile signalling. Continuous receptor occupancy desensitises and downregulates the receptor, so after a brief initial surge the net effect is suppression.
References
Related compounds
Gonadorelin
Synthetic gonadotropin-releasing hormone, identical to the native decapeptide. Used diagnostically and historically therapeutically.
Leuprolide
A long-acting GnRH agonist that produces sustained suppression of the reproductive axis through receptor downregulation. A widely used medicine in oncology and endocrinology.
Entry last reviewed 2026-10-11. Regulatory status and scientific understanding change; verify against primary sources before relying on anything here.